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目的探讨氟暴露工人血清白细胞介素２含量的变化及其意义。方法选取某铝厂工人６６人，测定血清氟、尿氟、尿氟硼酸根浓度（离子选择电极法）及血清ＩＬ－２含量（ＥＬＩＳＡ法）。结果氟暴露组血清氟、尿氟及氟硼酸根浓度明显高于对照组（Ｐ＜０．０１），其中血清氟浓度与工龄有关，低工龄组低于高工龄组（Ｐ＜０．０５），而尿氟和尿氟硼酸根浓度与工龄无关；氟暴露工人血清ＩＬ－２含量明显低于对照组，其中高工龄组又低于低工龄组，抑制率分别为２９．７％和１３．０％（Ｐ＜０．０５）。结论ＩＬ－２含量的下降是氟性免疫损伤的机理之一。
Objective To investigate the changes of serum interleukin-2 level in workers exposed to fluoride and its significance. Methods Sixty-six workers in an aluminum factory were selected to measure serum fluorine, urinary fluoride, urinary fluoroborate concentration (ion-selective electrode method) and serum IL-2 level (ELISA method). Results The levels of serum fluoride, urofluorine and fluoborate in the fluoride exposure group were significantly higher than those in the control group (P <0.01). The serum fluoride concentration was related to length of service, , While the concentrations of urinary fluoride and urinary fluoroborate had no relation with the length of service. The content of IL-2 in workers exposed to fluorosis was significantly lower than that in the control group, of which the high-service-age group was lower than the lower-service-age group with the inhibition rates of 29.7% and 13%, respectively. 0% (P <0.05). Conclusion The decrease of IL-2 level is one of the mechanisms of fluoroimmune damage.