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目的分析常州市武进区2005-2014年报告的麻疹疑似病例中接种含麻疹成分疫苗(Measles Containing Vaccine,MCV)后发热出疹疾病(Rash and Fever illness,RFIs)的发病情况,为武进区麻疹、风疹的有效控制提供依据。方法以该区2005-01/2014-12接种MCV后出现RFIs的57例病例为研究对象,采用酶联免疫吸附试验(ELISA),检测麻疹、风疹Ig M抗体。结果武进区2005-2014年接种MCV 503 281人次,发生RFIs 57例,年平均报告发生率为11.33/10万,所有RFIs的风疹Ig M均为阴性,麻疹Ig M阳性率为68.42%。病例间无聚集性和流行病学联系,病例主要集中在8~10月龄,89.47%的病例是首剂。病例发热高峰期为接种后第4~9 d,出疹高峰期为接种后第7~11 d。结论在消除麻疹阶段,应加强对接种MCV后RFIs病例的关注,接种MCV后出现RFIs的原因需要从病毒基因型别上进行确认。
Objective To analyze the incidence of Rash and Fever illness (RFIs) after measles containing vaccine (Measles Containing Vaccine, MCV) reported in Wujin District, Changzhou City in 2005-2014 suspected cases of measles, Provide the basis for the effective control of rubella. Methods Fifty-seven cases of RFIs after MCV inoculation from January 2005 to December 2014 were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to detect measles and rubella IgM antibodies. Results In Wujin District from 2005 to 2014, 503 281 MCVs were inoculated and 57 RFIs occurred. The annual average incidence was 11.33 / 100 000. The rubella Ig M of all RFIs was negative and the positive rate of measles IgM was 68.42%. No aggregation between cases and epidemiological linkages, the cases mainly concentrated in 8 to 10 months of age, 89.47% of cases are the first dose. The peak fever of cases was 4 ~ 9 days after inoculation, the peak of rash was 7 ~ 11 days after inoculation. Conclusion At the stage of eliminating measles, attention should be paid to the cases of RFIs after MCV inoculation. The reason of RFIs after MCV vaccination needs to be confirmed on the basis of genotype of virus.