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1 妊娠免疫妊娠是一种特殊的免疫状态,胎儿可以看作是一种异体移植物,在母体中生长发育而不遭到排斥。其机理是相当复杂的,其中主要是母体免疫功能和胎盘的屏障作用。在妊娠期母体免疫功能的研究中,尽管有些结论相互矛盾,但大部分文献已经证明孕妇的免疫功能低下,特别是细胞免疫更为明显。Nelson等(1973)发现孕妇盆腔淋巴结中,生发中心消失,淋巴细胞含量显著下降。但近来的研究证明,外周血中T细胞总数和亚群的比率没有变化。Baines(1977)认为妊娠晚期T细胞数量明显下降,而B细胞无明显变化。Petrucco等(1976)观察到孕期T细胞活性降低。Gehrt等(1981)亦发现孕妇淋巴细胞对抗原的增生反应在妊娠
1 pregnancy immune pregnancy is a special immune status, the fetus can be seen as a xenograft, growth and development in the mother without being excluded. The mechanism is quite complex, mainly maternal immune function and placental barrier function. In the study of maternal immune function during pregnancy, although some of the conclusions contradict each other, most of the literature has proved that pregnant women have low immunocompromise, especially cellular immunity. Nelson et al. (1973) found that in the pelvic lymph nodes of pregnant women, the germinal center disappeared and the lymphocyte content was significantly decreased. However, recent studies have shown that there is no change in the total number of T cells and the proportion of subpopulations in peripheral blood. Baines (1977) that the number of T-cells in late pregnancy decreased significantly, while B cells did not change significantly. Petrucco et al. (1976) observed decreased T cell activity during pregnancy. Gehrt et al. (1981) also found that pregnant women with lymphocyte proliferative response to antigen in pregnancy