论文部分内容阅读
将70例慢性乙型肝炎患者随机分为两组。治疗组先用强的松,40mg/天、30mg/天、20mg/天和10mg/天各1周,随后用聚肌胞,每天10mg 静脉注射,每天1次,连续4周;对照组用安慰剂,采用双盲法安排治疗和观察。于停药后半年判断最后疗效。治疗组 HBeAg 阴转率51.4%,对照组25.7%(P<0.05);治疗组 HBV—DNA 阴转及滴度下降者13例(65.0%),对照组4例(23.5%)(P<0.01)。治疗组治前 HBV—DNA 阴性者15例,治后无转阳者;对照组治前18例阴性者中,有7例(38.9%)转为阳性(P<0.01)。以上结果显示,强的松停药后继用聚肌胞治疗,不仅对 HBV 复制有一定抑制作用,而且在防止 HBV 复制再活动方面,也可能有一定作用。
Seventy patients with chronic hepatitis B were randomly divided into two groups. Treatment group with prednisone, 40mg / day, 30mg / day, 20mg / day and 10mg / day for 1 week, followed by poly inoculation, 10mg daily intravenous injection, once daily for 4 weeks; control group with comfort Agent, using double-blind treatment and observation arrangements. Six months after stopping to determine the final effect. In the treatment group, HBeAg negative conversion rate was 51.4% in the control group and 25.7% in the control group (P <0.05). In the treatment group, 13 cases (65.0% ). In the treatment group, 15 cases were HBV-DNA negative before treatment, and no positive control was found in the treatment group. 7 cases (38.9%) in the control group were negative before the treatment (P <0.01). The above results show that prednisone withdrawal followed by poly-cell therapy, not only has a certain inhibitory effect on HBV replication, but also in the prevention of HBV replication re-activity, may also have a role.