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采用ＥＬＩＳＡ法测定３２例急性白血病患者血浆血小板α颗粒膜蛋白（ＧＭＰ－１４０）和血管性假血友病因子（ｖＷＦ）水平。结果发现，初治和复发患者血浆ＧＭＰ－１４０、ｖＷＦ浓度较正常对照显著升高（Ｐ＜０．０１），完全缓解后明显下降至正常水平；血浆ＧＭＰ－１４０与ｖＷＦ浓度间呈显著正相关，外周血白血病细胞数与血浆ＧＭＰ－１４０浓度间呈显著正相关。结果提示，急性白血病患者体内存在血小板活化程度增高、血管内皮细胞受损等病理改变。检测血浆ＧＭＰ－１４０和ｖＷＦ水平有助于疾病严重程度的了解及预后的评估。
ELISA was used to determine plasma platelet alpha granule membrane protein (GMP-140) and von Willebrand disease (vWF) levels in 32 patients with acute leukemia. The results showed that plasma concentrations of GMP-140 and vWF were significantly higher in patients with primary and relapse than those in normal controls (P<0.01), and significantly decreased after complete remission to normal levels; there was a significant positive correlation between plasma GMP-140 and vWF concentrations. There was a significant positive correlation between the number of leukemic cells in the peripheral blood and the plasma GMP-140 concentration. The results suggest that there are pathological changes such as increased platelet activation and damage to vascular endothelial cells in patients with acute leukemia. Detection of plasma GMP-140 and vWF levels contributes to the understanding of disease severity and to the evaluation of prognosis.