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目的：观察自发性高血压大鼠（ＳＨＲ）血浆神经肽Ｙ（ＮＰＹ）、血管平滑肌细胞（ＶＳＭＣ）ＮＰＹ受体的变化及美托洛尔、培哚普利干预的影响。方法：用放射免疫分析法和受体放射配体结合分析法测定血浆ＮＰＹ及ＶＳＭＣ上ＮＰＹ受体密度的变化。结果：ＳＨＲ血浆ＮＰＹ含量明显高于ＷＫＹ，血压的高低与血浆ＮＰＹ的量呈明显的正相关。培哚普利降压的同时亦降低ＳＨＲ血浆ＮＰＹ的量，而美托洛尔对ＮＰＹ量则无影响；培哚普利引起ＮＰＹ受体密度上调，而美托洛尔则使ＮＰＹ受体下调。结论：ＮＰＹ在高血压的发生、发展中可能起到重要的作用；在培哚普利的降压作用中可能有血浆ＮＰＹ含量下降这一因素参与，美托洛尔致ＮＰＹ受体密度下调可能在预防主动脉管壁结构重建中发挥着一定的作用。
Objective: To observe the changes of neuropeptide Y (NPY) and vascular smooth muscle cells (NPY) in spontaneously hypertensive rats (SHR) and the effects of metoprolol and perindopril intervention. Methods: The changes of NPY receptor density in plasma NPY and VSMC were determined by radioimmunoassay and receptor radioligand binding assay. Results: The content of plasma NPY in SHR was significantly higher than that in WKY. The level of plasma NPY was positively correlated with the level of blood pressure. Perindopril also reduced blood pressure and reduced the amount of NPY in SHR plasma, whereas metoprolol had no effect on the amount of NPY; perindopril caused an increase in NPY receptor density, while metoprolol down-regulated NPY receptor . CONCLUSION: NPY may play an important role in the occurrence and development of hypertension. In the hypotensive effect of perindopril, there may be a factor involved in the decrease of NPY content in plasma. Metoprolol may reduce the density of NPY receptor It plays a certain role in the prevention of aortic wall reconstruction.