60年代以来,一些研究表明,对于局部晚期头颈部肿瘤患者采用化疗(特别是含有顺铂和5-FU的方案)和放疗相联合与单纯的放疗相比,肿瘤的反应性有明显增高。作者为此对不能手术的局部晚期患者进行了术前联合应用化、放疗的Ⅱ期临床试验。40例患者均为临床Ⅲ-Ⅳ期的口腔或口咽部鳞 Since the 1960s, some studies have shown that the use of chemotherapy (particularly regimens containing cisplatin and 5-FU) and radiotherapy in combination with radiotherapy for locally advanced head and neck cancers has significantly increased tumor response. The authors conducted a phase II clinical trial of preoperative combined use of radiotherapy for locally inoperable patients with locally advanced disease. All 40 patients were clinically stage III-IV oral or oropharyngeal scales