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测定血清肌酸激酶(SCK)水平已被认为是检出X-连锁遗传的Duchenne和Becker肌营养不良携带者最可靠的简单方法,其缺点是约有25％的假阳性。较年轻的妇女携带者检出率较好,因为携带者酶的水平随年龄的增长而降低。Moser等人曾报道,即使是正常人,SCK水平也随年龄的增长而降低,但Griffiths等人在正常对照者中未发现任何明显的年龄影响。据推测,如果在儿童期测定携带者的SCK水平,假阳性率可能降低。因此确定正常成年妇女和儿童SCK值的正常范围是很重要的。作者从75名女孩(年龄在1个月至15岁之间)采取静脉血,女孩中无一人有神经系
Determining serum creatine kinase (SCK) levels has been considered the simplest and easiest way to detect X-linked inherited Duchenne and Becker muscular dystrophy carriers with the drawback of about 25% false-positives. The detection rate of younger women carriers is better, because carriers of enzyme levels decreased with age. Moser et al. Have reported that even normal controls, SCK levels also decrease with age, but Griffiths et al. Did not find any significant age effect in normal controls. Presumably, if SCK levels were measured in childhood, the false-positive rate may be reduced. It is therefore important to determine the normal range of SCK values for normal adult women and children. The authors took venous blood from 75 girls (between 1 month and 15 years of age), none of the girls had a nervous system