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目的:探讨血清肿瘤标志物CA125、CA72-4与超声血流联合检测对卵巢上皮恶性肿瘤的诊断价值。方法:选择49例卵巢上皮恶性肿瘤患者和52例卵巢良性上皮肿瘤患者,用放射免疫法测量血清CA125、CA72-4水平,并行彩色多普勒超声检查肿瘤内部血流分布情况,测量血流阻力指数(RI)、搏动指数(PI),并将诊断结果与病理结果进行对照。结果:血清CA125、CA72-4、RI、PI单检对卵巢上皮恶性肿瘤诊断的灵敏度分别为75.5%、65.3%、77.6%、73.5%;CA125+CA72-4、RI+PI、CA125+CA72-4+RI、CA125+CA72-4+RI+PI联检对卵巢上皮恶性肿瘤诊断的灵敏度分别为87.8%、83.7%、89.8%、95.9%,联检诊断敏感性提高,与单检敏感性比较差异有统计学意义(P<0.05)。联检的准确度与诊断价值也较单检高。结论:血清CA125、CA72-4与超声血流检测联合应用能提高对卵巢上皮恶性肿瘤诊断的敏感性及准确性,能成为早期诊断卵巢上皮恶性肿瘤较好的方法。
Objective: To investigate the diagnostic value of serum tumor markers CA125, CA72-4 combined with ultrasonic blood flow in the diagnosis of epithelial ovarian cancer. Methods: Forty-nine patients with epithelial ovarian cancer and 52 patients with benign epithelial ovarian tumor were enrolled in this study. The levels of serum CA125 and CA72-4 were measured by radioimmunoassay. The distribution of blood flow inside the tumor was examined by color Doppler sonography. Index (RI), pulsatility index (PI), and the diagnostic results and pathological results were compared. Results: The sensitivity of single serum CA125, CA72-4, RI and PI was 75.5%, 65.3%, 77.6% and 73.5% respectively. The sensitivity of CA125 + CA72-4, RI + PI and CA125 + CA72- The sensitivities of 4 + RI, CA125 + CA72-4 + RI + PI in the diagnosis of epithelial ovarian cancer were 87.8%, 83.7%, 89.8% and 95.9%, respectively. The sensitivity of the combined test was higher than that of the single test Statistical significance (P <0.05). Joint inspection of the accuracy and diagnostic value is higher than the single check. Conclusion: The combination of serum CA125, CA72-4 and ultrasonic blood flow detection can improve the sensitivity and accuracy of the diagnosis of ovarian epithelial malignancies, and can be a good method for early diagnosis of epithelial ovarian cancer.