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利用美国《化学文摘》(CA)检索对映异构体的有关文献时,不论使用化学物质索引,还是使用分子式索引,都必须熟悉对映异构体的立体化学标识,否则难以奏效,因为C A中对映异构体的立体化学标识与通常使用的标识有所不同。例如,通常抗生素类药物氯霉素(Chloromycetin) (A)的立体化学标识有两种:“D-(-)-threo-”和“1R,2R-(-)-”(?)],而CA却使用“[R-(R~*,R~*)]-”标识;氯霉素的对映体(B)使用“[S(R~*,R~*)]-”标识:氯霉素的外消旋体合霉素(Syntomycin)[(A)
When using the U.S. Chemical Abstracts (CA) to search for enantiomeric excercises, either the chemical index or the molecular index must be familiar with the stereochemical identity of the enantiomer, otherwise it will not work because CA The stereochemical identity of the mid-enantiomer is different from the one commonly used. For example, there are generally two types of stereochemical labels for the antibiotic drug Chloromycetin (A): “D - (-) - threo-” and “1R, 2R - (-) -” CA was labeled with “[R- (R ~ *, R *)] -”; the enantiomer of chloramphenicol (B) was labeled with " The racemic mycophenolate (Syntomycin) [(A)