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对20例地方性克汀病患者用药物甲状腺片、恢智片和教育训练等方法进行综合治疗。治疗前患者心电图检出异常者为18例,治疗后2、5、9个月时做心电图检查分别下降到16、15、11例,至9个月时异常检出率显著低于治疗前(P<0.05)。18例中有效的16例。T波低平或倒置由治疗前的13例降到4例(P<0.01),3例窦性心动过缓治疗后全部消失。QRSⅠ+Ⅱ+Ⅲ平均电压增加0.69mV(P<0.001),TⅠ+Ⅱ+Ⅲ电压平均增加0.15mV(P<0.01),Tv_1+v_5平均增加0.1mV(P<0.05)。低电压、Q—T延长治疗后也有所减少。粘液水肿型和神经型患者心电图异常率分别由治疗前的8例和5例下降到3例和2例,治疗前后有显著差异(P<0.05)。血清T_3和T_4治疗后较治疗前都有增加,尤其T_4平均增加3.43μg％ml(P<0.05)。因此,作者认为改善地方性克汀病患者的甲状腺功能,可使心电图异常减轻。
20 cases of endemic cretinism patients with drug thyroid tablets, recovery tablets and education and training methods such as comprehensive treatment. ECG before treatment in patients with abnormalities were 18 cases, 2,5,9 months after treatment to do electrocardiogram were decreased to 16,15,11 cases, to 9 months, the abnormal detection rate was significantly lower than before treatment ( P <0.05). Eighteen cases were effective in 16 cases. T wave low flat or inverted by the treatment of 13 cases dropped to 4 cases (P <0.01), 3 cases of sinus bradycardia disappeared after treatment. The average voltage of QRSⅠ + Ⅱ + Ⅲ increased by 0.69mV (P <0.001). The average voltage of TⅠ + Ⅱ + Ⅲ increased by 0.15mV (P <0.01) and the average of Tv_1 + v_5 increased by 0.1mV (P <0.05). Low voltage, Q-T extended treatment also decreased. The abnormal rate of electrocardiogram in mucoid edema and neurotic patients decreased from 8 cases and 5 cases before treatment to 3 cases and 2 cases, respectively, with significant difference before and after treatment (P <0.05). Serum T_3 and T_4 treatment than before treatment have increased, especially T_4 an average increase of 3.43μg% ml (P <0.05). Therefore, the authors believe that to improve thyroid function in patients with endemic cretinism, abnormal ECG can be reduced.