先证者，男，39岁，反复发作的口腔、生殖器溃疡10年，腰、背、位关节明显设疼，弯腰、转体、行走困难6年，脚背部毛囊炎样皮损3年，间断发热半年。腰椎CT片示骨质增生和椎间隙变窄。HLA-B27（＋）。针刺反应（＋）。其一、二级亲属中另有不同程度的强直性脊柱炎患者5位，均不伴有白塞氏病。本家系调查提示，不仅强直性脊椎炎具有明显遗传倾向．而且决定强直性脊椎炎和白塞氏病的基因位点，具有一定相互关联。 The proband, male, 39 years old, repeated episodes of oral and genital ulcers for 10 years, waist, back, bit joint pain, bending, turning, walking difficulties 6 years, Intermittent fever for six months. Lumbar CT showed bone hyperplasia and intervertebral space narrowing. HLA-B27 (+). Acupuncture reaction (+). One, two relatives in different degrees of ankylosing spondylitis in patients with 5, are not associated with Behcet’s disease. The pedigree investigation suggests that not only ankylosing spondylitis has a clear genetic predisposition. But also determines the genetic locus of ankylosing spondylitis and Behcet’s disease, with certain interrelated.