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以4-氨基-3-(4-甲基-1,2,3-噻二唑)-1,2,4-三唑-5-硫酮为原料,与醛在冰乙酸中回流制得15个新型4-取代亚氨基-3-(4-甲基-1,2,3-噻二唑)-1,2,4-三唑-5-硫酮化合物,其结构经IR、1H NMR及元素分析表征,其中,化合物5c的结构经单晶测试确证,该晶体属单斜晶系,P2(1)/c空间群,晶胞参数a=1.403 7(3)nm,b=1.570 5(3)nm,c=0.6864(14)nm,β=102.06(3)°,V=1.4798(5)nm3,Z=4,F(000)=656。初步的抑菌活性测试结果表明;所有化合物对黄瓜灰霉病菌Botrytis cinerea都有较好的抑制作用,化合物5l的抑制率达87%,5c、5d和5f的抑制率在78%左右;5a对小麦赤霉病菌Gibberella zeae的抑制率为78.7%;5m对西瓜炭疽病菌Colletotrichum lagenarium的抑制率为65.6%。
Starting from 4-amino-3- (4-methyl-1,2,3-thiadiazole) -1,2,4-triazole-5-thione with aldehyde in glacial acetic acid, 15 A novel 4-substituted imino-3- (4-methyl-1,2,3-thiadiazole) -1,2,4-triazole-5-thione compound was prepared by IR, 1H NMR and Elemental analysis shows that the structure of compound 5c is confirmed by single crystal test. The crystal belongs to the monoclinic space group P2 (1) / c with a = 1.403 7 (3) nm and b = 1.570 5 ( 3) nm, c = 0.6864 (14) nm, β = 102.06 (3) °, V = 1.4798 (5) nm3, Z = 4, F (000) = 656. The results of preliminary antibacterial activity test showed that all the compounds had a good inhibitory effect on Botrytis cinerea, the inhibitory rate of compound 5I was 87%, that of 5c, 5d and 5f was about 78% The inhibition rate of Gibberella zeae was 78.7%. The inhibition rate of 5m to Colletotrichum lagenarium was 65.6%.