淋巴细胞在牙周炎发病机理中的作用自从本世纪初就开始讨论,但至今仍不清楚。近几年,一些研究者发现牙周病原菌含有非特异地引起B淋巴细胞大量增生和分化的成分,导致B淋巴细胞的多克隆激活,并且激活的B淋巴细胞可以释放多种效应分子,包括免疫球蛋白,白细胞介素-1,白细胞介素-2,干扰素-γ,B细胞生长因子,抑制B细胞因子,淋巴毒素,肿瘤坏死因子,白细胞移动抑制因子等。B淋巴细胞可以通过抗体、自身抗体和其产生的上述效应分子引起牙周组织破坏。 The role of lymphocytes in the pathogenesis of periodontitis has been discussed since the beginning of this century, but it is still unclear. In recent years, some researchers have found that periodontal pathogens contain components that cause non-specific proliferation and differentiation of B lymphocytes, resulting in polyclonal activation of B lymphocytes, and activated B lymphocytes can release a variety of effector molecules, including immunoglobulins. Protein, interleukin-1, interleukin-2, interferon-gamma, B-cell growth factor, B-cell inhibitory factor, lymphotoxin, tumor necrosis factor, leukocyte migration inhibitory factor, etc. B lymphocytes can cause periodontal tissue destruction through antibodies, autoantibodies, and the above-described effector molecules that they produce.