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泛素羧基水解酶UCHL1和UCHL3在哺乳类动物神经退变、生殖细胞发生与受精,以及肿瘤发生过程中具有重要作用。本文对UCHL1和UCHL3在精子发生与成熟、卵母细胞发生和受精过程中的作用进行了综述,并通过绘制图谱作了归纳。UCHL1和UCHL3具有不同的底物特异性,参与生精过程中正常的细胞凋亡调控和卵母细胞发育过程中的减数分裂调节,并通过不同的途径影响精卵识别和结合而抑制多精受精。UCHL1可以与Ptov1,CDK1以及Jab1结合,初步用于解释其作用的分子机制。目前报道的UCH家族成员主要包括UCHL1和UCHL3,对其它家族成员的研究尚待开展,特别是各成员之间的进化关系,以及彼此的结构和功能差异等都需要进一步研究阐明。
Ubiquitin carboxylase UCHL1 and UCHL3 play an important role in mammalian neurodegeneration, germ cell development and fertilization, and tumorigenesis. In this paper, the roles of UCHL1 and UCHL3 in the process of spermatogenesis and maturation, oocyte generation and fertilization are summarized and drawn by drawing the map. UCHL1 and UCHL3 have different substrate specificity and are involved in the regulation of normal apoptosis and meiosis in oocyte development during spermatogenesis and inhibit the multi-sperm through different pathways that affect sperm-egg recognition and binding Fertilization. UCHL1 can be combined with Ptov1, CDK1 and Jab1, initially to explain the molecular mechanism of its action. The currently reported members of the UCH family mainly include UCHL1 and UCHL3. The research on other family members has yet to be carried out. In particular, the evolutionary relationships among the members and the differences in their structures and functions need to be further elucidated.