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小白鼠耐缺氧实验是我国广泛用作筛选抗心绞痛药的一种辅助方法。肾上腺素增加组织耗氧量、降低动物的耐缺氧能力,而心得安的作用则相反。因此,它们常作为具有典型作用的代表药物而应用于耐缺氧实验。按理,肾上腺素和心得安联用应显示对抗作用。然而,我们给小鼠腹腔注射肾上腺素时,并不与心得安对抗,反而表现协同作用;如肾上腺素为皮下注射,则与心得安对抗。为此,对这一现象进行了较系统的观察,对引起这一现象的原因作了初步探讨,现报告于后。方法与结果一、对耐缺氧时间和耗氧量的影响用我们自制的小白鼠耐缺氧时间和耗氧量测定装置(见图)实验。这种装置的结构是:在一瓷盘内放一容量为100毫升的小烧杯,另取一大烧杯(容量为250毫升),例置并套叠于小
Anti-hypoxia mice experiment is widely used as a screening method of anti-anginal medicine ancillary methods. Epinephrine increases tissue oxygen consumption, reduce animal hypoxia tolerance, and the effect of propranolol is the opposite. Therefore, they are often used as representative drugs with typical effects in hypoxia-tolerant experiments. Logically, adrenaline and the combination of security should show confrontation. However, when we intraperitoneally injected epinephrine into mice, we did not show any sympathy with propranolol but showed a synergistic effect. For example, epinephrine was administered subcutaneously in combination with propranolol. To this end, the phenomenon of a more systematic observation of the causes of this phenomenon made a preliminary discussion, the report is later. Methods and Results First, the impact on hypoxia time and oxygen consumption with our own mouse anti-hypoxia time and oxygen consumption measuring device (see Figure) experiment. The structure of this device is: put a small beaker with a capacity of 100 ml in a porcelain plate, another big beaker (capacity of 250 ml), set and nested in a small