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21-羟化酶缺陷所致先天性肾上腺增生的特征是皮质醇分泌不足、血浆雄激素及促孕复合物(Progestational Compounds)水平过高,并有醛固酮分泌不足。在治疗中,判断雄激素分泌情况的最常用指标是尿17-甾酮(17-KS)。该法须收集24小时尿液,收集常有困难。因此作者探讨了改用测定血浆的雄激素作为指标的可能性。检测对象为2～25岁的24例21-羟化酶缺陷患者(12例女性和12例男性)及38例6～42岁的健康对照者。作者试图从中找出与17-KS最密切相关的血浆雄激素。血浆雄激素与尿17-KS之间的相关性用线性回归分析法确定。
21-hydroxylase deficiency caused by congenital adrenal hyperplasia is characterized by insufficient secretion of cortisol, plasma androgen and progestational compounds (Progestational Compounds) levels are too high, and aldosterone secretion. In therapy, the most common indicator of androgen secretion is urinary 17-ketosterone (17-KS). The law to collect 24-hour urine, often difficult to collect. The authors therefore explored the possibility of switching to androgens for the measurement of plasma as an indicator. Twenty-four patients with 21-hydroxylase deficiency (12 women and 12 males) aged 2 to 25 years and 38 healthy controls aged 6 to 42 years were included in the study. The authors sought to identify the plasma androgens most closely related to 17-KS. The correlation between plasma androgens and urinary 17-KS was determined by linear regression analysis.