近年来,常染色体隐性基因Mahoganoid已成为科学家的研究热点之一。该基因编码蛋白Md具有特征的C3HC4RING结构域,基于这一结构,认为该蛋白可能是作为一种E3泛肽连接酶起作用。Mahoganoid基因在生物体内广泛分布,并具有多个等位基因,在色素形成,体质量控制,神经系统退行性变及生殖系统方面都发挥重要的生理和病理作用。介绍Mahoganoid基因特点、基因表达、基因功能及分子作用机理。为以后的课题研究提供方向。 In recent years, autosomal recessive gene Mahoganoid has become one of the hot topics of scientists. This gene encodes the C3HC4RING domain that is characteristic of the protein Md. Based on this structure, it is believed that this protein may function as an E3 ubiquitin ligase. The Mahoganoid gene is widely distributed in organisms and has multiple alleles and plays an important physiological and pathological role in pigmentation, body mass control, nervous system degeneration and reproductive system. Mahoganoid gene characteristics, gene expression, gene function and molecular mechanism of action are introduced. For the future research to provide direction.