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[目的]了解新生儿接种乙肝疫苗后的免疫效果和对全程免后低/无应答者的再免疫效果。[方法]2009年,在威海市3个市(区)抽取7～12月龄儿童1 102名,按“0,1,6”程序接种3剂次5μg啤酒酵母重组乙肝疫苗(HepB-SC),对其中低/无应答者分别按上述程序再次接种不同种类和剂量的乙肝疫苗,检测调查对象血清抗-HBs水平,观察变化情况。[结果]检测儿童1 102名,3剂乙肝疫苗接种后,抗-HBs阳性率为98.19%(正常应答率为84.66%、低应答率为13.52%),无应答率为1.81%;GMC为800.94mIU/ml。检测再免疫的低/无应答儿童127名(17名无应答、110名低应答),抗-HBs的GMC,再免疫前为45.72mIU/ml,1剂次再免疫后为1 373.50mIU/ml(P<0.01);3剂次再免疫后检测其中100名(14名无应答、86名低应答),抗-HBs的GMC上升为1 763.33mIU/ml,与1剂次后的差异无统计学意义(P>0.05)。[结论]按现行免疫程序乙肝疫苗全程免疫后,可以取得良好的免疫应答。对低/无应答者按相同免疫程序再次接种3针后,抗-HBs水平有较大幅度提高。
[Objective] To understand the immune effect of neonates vaccinated with Hepatitis B vaccine and the re-immunization effect of low post-transplant / non-responders. [Method] In 2009, 1022 children aged 7-12 months were collected in 3 cities (districts) of Weihai City. Three doses of 5μg recombinant Saccharomyces cerevisiae HepB- SC). The low / non-responders were re-vaccinated with different types and doses of hepatitis B vaccine according to the above procedure respectively, and the levels of serum anti-HBs in the surveyed subjects were measured to observe the changes. [Results] The positive rate of anti-HBs was 98.19% (the normal response rate was 84.66%, the low response rate was 13.52%), and the non-response rate was 1.81%. The GMC was 800.94 mIU / ml. 127 (17 non-responders and 110 low responders) children with / without response to re-immunization were tested for GMC anti-HBs, 45.72 mIU / ml before re-immunization and 1 373.50 mIU / ml after 1 re-immunization (P <0.01). After three doses of immunization, 100 (14 non-responders and 86 low responders) were detected. The GMC of anti-HBs increased to 1 763.33 mIU / ml, with no statistical difference Significance (P> 0.05). [Conclusion] According to the current immunization program, the whole immunization of Hepatitis B vaccine can achieve a good immune response. Anti-HBs levels increased significantly after re-inoculation of 3 doses of low / no responders according to the same immunization schedule.