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目的对比分析多西他赛和顺铂联合放射疗法同步治疗局部晚期鼻咽癌的临床疗效。方法将46例局部晚期鼻咽癌患者随机分为对照组与研究组,各23例,对照组采用顺铂联合放射疗法,研究组采用多西他赛联合放射疗法。观察对比两组患者治疗后1个月疗效与不良反应情况。结果研究组鼻咽部病灶治疗总有效率为84.44%,对照组为82.22%,差异无统计学意义(P=0.45);研究组颈部淋巴结治疗总有效率为85.44%,对照组为86.67%,差异无统计学意义(P=0.35);研究组胃肠道反应、口腔黏膜反应等发生率明显低于对照组,差异有统计学意义(P<0.05)。结论多西他赛联合放射疗法治疗局部晚期鼻咽癌疗效和顺铂联合放射疗法接近,但该疗法不良反应少,值得推广应用。
Objective To compare the clinical efficacy of docetaxel and cisplatin combined with radiotherapy in the concurrent treatment of locally advanced nasopharyngeal carcinoma. Methods Forty-six patients with locally advanced nasopharyngeal carcinoma were randomly divided into control group and study group, with 23 cases in each group. Cisplatin combined with radiotherapy was used in the control group and Docetaxel combined with radiotherapy was used in the study group. Observed and compared two groups of patients 1 month after treatment efficacy and adverse reactions. Results The total effective rate of nasopharyngeal lesions was 84.44% in the study group and 82.22% in the control group, with no significant difference (P = 0.45). The total effective rate of the treatment group was 85.44% in the cervical lymph node and 86.67% in the control group (P = 0.35). The incidence of gastrointestinal tract reaction and oral mucosal reaction in the study group was significantly lower than that in the control group (P <0.05). Conclusion Docetaxel combined with radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma and cisplatin combined with radiation therapy approach, but the adverse reactions of the therapy less worthy of promotion.