新药临床试验都经过多测量与多比较后才作出结论,但多测量与多比较常不同于单次测量及比较的分析方法。本文提出一些常被临床医生所忽略的问题,其中包括多组比较、重复测量、次组分析及中间分析。希望能引起临床医生的注意,并希新药试验的统计分析能在更科学的基础上得出更为可靠的结论。 New drug clinical trials have been more than the measurement and more after the conclusion, but more than one measurement and more often different from a single measurement and comparative analysis. This article presents some issues that are often overlooked by clinicians, including multiple comparisons, repeat measures, subgroup analyzes, and intermediate analyzes. Hoping to arouse the attention of clinicians and hope that the statistical analysis of new drug trials will lead to more reliable conclusions on a more scientific basis.