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目的:经导管建立冠状动脉微栓塞模型,观察冠脉微栓塞后冠脉阻抗的变化情况。方法:15头小型猪,通过导管方法建立急性冠脉微栓塞模型,观察微栓塞前、微栓塞后2、6h及1周时冠脉阻抗和冠脉阻抗储备的变化情况。结果:在微栓塞前、微栓塞后2h、6h及1周时基础冠脉阻抗分别为2.448±1.891mmHg·mL-1·s-1,3.229±2.872mmHg·mL-1·s-1,3.197±3.227mmHg·mL-1·s-1和3.466±2.683mmHg·mL-1·s-1;冠脉一次谐波阻抗分别为0.538±0.559mmHg·mL-1·s-1,1.604±1.727mmHg·mL-1·s-1,0.834±0.858mmHg·mL-1·s-1和1.233±1.809mmHg·mL-1·s-1;最小冠脉阻抗分别为1.778±1.352mmHg·mL-1·s-1,2.577±2.276mmHg·mL-1·s-1,2.710±2.733mmHg·mL-1·s-1和3.039±2.671mmHg·mL-1·s-1;冠脉一次谐波最小阻抗分别为0.388±0.395mmHg·mL-1·s-1,0.947±0.844mmHg·mL-1·s-1,1.639±1.9780mmHg·mL-1·s-1,0.716±0.624mmHg·mL-1·s-1(其中微栓塞后6h与微栓塞前相比有显著差异,P<0.05)。冠脉阻抗储备分别为1.463±0.235,1.265±0.105,1.160±0.068和1.276±0.266(其中微栓塞后6h与微栓塞前相比有显著差异,P<0.05)。对冠脉阻抗数据进行校正后发现,冠脉阻抗储备和冠脉一次谐波最小阻抗是反映微栓塞后微循环功能变化最为敏感的指标。结论:急性冠脉微栓塞后冠脉阻抗呈逐渐升高又恢复正常的变化趋势,而冠脉阻抗储备呈逐渐下降又恢复正常的变化趋势。
OBJECTIVE: To establish a coronary micro-embolization model by catheterization and observe the change of coronary impedance after coronary micro-embolization. Methods: Fifteen miniature pigs were used to establish acute coronary microembolization model by catheterization. Changes of coronary impedance and coronary impedance reserve were observed before and at 2, 6h and 1 week after microembolization. Results: The baseline coronary impedance at 2h, 6h and 1 week after micro-embolization were 2.448 ± 1.891mmHg · mL-1 · s-1, and 2.29 ± 2.872mmHg · mL-1 · s-1, ± 3.227mmHg · mL-1 · s-1 and 3.466 ± 2.683mmHg · mL-1 · s-1 respectively. The first order harmonic impedance of the coronary artery was 0.538 ± 0.559mmHg · mL-1 · s-1 and 1.604 ± 1.727mmHg, respectively · ML-1 · s-1, 0.834 ± 0.858mmHg · mL-1 · s-1, and 1.233 ± 1.809mmHg · mL-1 · s-1. The minimum coronary impedance were 1.778 ± 1.352mmHg · mL-1 · s-1, 2.577 ± 2.276mmHg · mL-1 · s-1, 1.710 ± 2.733mmHg · mL-1 · s-1 and 3.039 ± 2.671mmHg · mL-1 · s-1; Were 0.388 ± 0.395 mmHg · mL-1 · s-1, 0.947 ± 0.844 mmHg · mL-1 · s-1, 1.6939 ± 1.9780 mmHg · mL-1 · s-1, 0.716 ± 0.624 mmHg · mL-1 · s-1 (6h after micro-embolization compared with before the micro-embolization was significantly different, P <0.05). Coronary impedance reserve was 1.463 ± 0.235,1.265 ± 0.105,1.160 ± 0.068 and 1.276 ± 0.266, respectively (P <0.05, 6h after micro-embolization). Correct the coronary impedance data and find that the coronary impedance reserve and the minimum impedance of coronary first harmonic are the most sensitive indexes to reflect the changes of microcirculation function after micro-embolization. Conclusion: Coronary impedance gradually increased and returned to normal trend after acute coronary microembolization, and coronary resistance reserve gradually declined and returned to normal trend.