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目的观察慢性乙型肝炎患者血液透析后血清β2-微球蛋白、纤维化指标与血小板参数的变化情况,为该类患者的诊断与治疗提供参考依据。方法选取2014年1月-2016月2月医院收治33例慢性乙型肝炎患者血液透析后为A组,同时期33例血液透析无乙型肝炎者为B组,33名健康同龄者为C组,将3组受试者血清β2-微球蛋白、纤维化指标与血小板参数进行比较,并比较A组中轻度、中度及重度慢性乙型肝炎患者的上述血液指标。结果 A组血清β2-微球蛋白水平为(31.23±3.41)ug/ml,明显高于B组(21.25±2.63)ug/ml及C组(1.15±0.20)ug/ml,血清纤维化指标与血小板参数也均高于B组及C组,B组上述指标则高于C组,A组中重度乙肝患者的检测结果高于轻度及中度乙肝患者,中度乙肝患者则高于轻度乙肝患者,差异均有统计学意义(P<0.05)。结论血液透析合并慢性乙型肝炎患者血清β2-微球蛋白、纤维化指标与血小板参数均呈现高表达状态,且肝炎严重程度对其影响较大,因此,应注意对血液透析合并慢性乙型肝炎患者上述指标的监测与改善。
Objective To observe the changes of serum β2-microglobulin, fibrosis indexes and platelet parameters after hemodialysis in patients with chronic hepatitis B, and provide reference for the diagnosis and treatment of these patients. Methods A total of 33 patients with chronic hepatitis B who underwent hemodialysis from January 2014 to February 2016 in our hospital were enrolled as group A, 33 patients with hemodialysis without hepatitis B as group B and 33 healthy cohorts as group C The serum β2-microglobulin, fibrosis index and platelet parameters of three groups of subjects were compared, and the above blood parameters of patients with mild, moderate and severe chronic hepatitis B in group A were compared. Results Serum β2-microglobulin level in group A was (31.23 ± 3.41) ug / ml, which was significantly higher than that in group B (21.25 ± 2.63) μg / ml and group C (1.15 ± 0.20) ug / ml Platelet parameters were also higher than those in group B and group C, while those in group B were higher than those in group C. The detection results of moderate and severe hepatitis B in group A were higher than those in mild and moderate hepatitis B patients, moderate hepatitis B patients were higher than those in mild hepatitis B patients Hepatitis B patients, the differences were statistically significant (P <0.05). Conclusion Serum β2-microglobulin, fibrosis index and platelet parameters of patients with hemodialysis and chronic hepatitis B are highly expressed, and the severity of hepatitis has a greater impact on it. Therefore, we should pay attention to hemodialysis combined with chronic hepatitis B Patients monitoring and improvement of the above indicators.