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目的探讨QT间期离散度(QTd)和血清心肌肌钙蛋白(cTnI)在评价新生儿窒息后心肌损伤的价值,以及对预后的评价。方法将62例新生儿窒息患儿分为轻度、重度二组,选择28例在日龄、性别之间无差异的无窒息的新生儿作为对照组,分别检测其血清心肌肌钙蛋白I(cTnI),并在安静或睡眠情况下描记心电图,测定QTd值。结果窒息组cTnI、QTd较对照组明显升高(P<0.05),且重度窒息组与轻度窒息组也有统计学差异(P<0.01)。结论血清中CTn-I可作为新生儿窒息后心肌损害程度的敏感指标,且QTd比CTn-I对心肌的损害的判断具有特异性。
Objective To investigate the value of QTd and cTnI in the evaluation of myocardial injury after neonatal asphyxia and to evaluate the prognosis. Methods Sixty-two neonates with asphyxia were divided into mild and severe groups. 28 neonates without asphyxia who had no difference between days and sex were selected as the control group. Serum cardiac troponin I cTnI) and electrocardiogram was recorded under quiet or sleep conditions to determine the QTd value. Results The cTnI and QTd in asphyxia group were significantly higher than those in control group (P <0.05). There was also significant difference between severe asphyxia group and mild asphyxia group (P <0.01). Conclusion Serum CTn-I can be used as a sensitive indicator of neonatal asphyxia myocardial damage, and Qtd than CTn-I on the determination of myocardial damage has specificity.