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登革病毒(dengue virus,DENV)属于黄病毒科黄病毒属,是具有包膜的单股正链RNA病毒。病毒可通过埃及伊蚊和白纹伊蚊传播,引起登革热和登革休克综合征,广泛流行于热带和亚热带地区,全球流行超过100个国家。登革病毒依赖包膜蛋白E蛋白构象的改变,从而发生病毒包膜和宿主细胞膜之间的融合将病毒核酸传递入细胞质中,但其感染入胞机理尚不十分清楚。本文就登革病毒相关E蛋白入胞机制的最新研究进展作一简要综述。
The dengue virus (DENV) belongs to the genus Flaviviridae and is an enveloped single-stranded positive-sense RNA virus. The virus is transmitted through Aedes aegypti and Aedes albopictus, causing dengue fever and dengue shock syndrome, widespread in the tropics and subtropics and has a global epidemic in more than 100 countries. The dengue virus relies on conformational changes of the envelope protein E, resulting in the fusion between the viral envelope and the host cell membrane, which transfers the viral nucleic acid into the cytoplasm, but the mechanism of infection into the cell is not well understood. This review summarizes the recent progress in the mechanism of dengue virus-associated E protein entry.