Repurposing verapamil for prevention of cognitive decline in sporadic Alzheimer 's disease

来源 :中国神经再生研究(英文版) | 被引量 : 0次 | 上传用户:zdhm
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Dementia is currently the only leading cause of death that is still on the rise, with its overall costs already surpassing those of cancer and heart disease combined, it has developed into a worldwide crisis. In response to its serious and far-reaching effects, the US government has established the “National Alzheimer\'s Project Act” (Public Law 111-375), which aims to prevent and successfully manage Alzheimer\'s disease (AD), the most common cause of dementia, by 2025. Unfortunately, the incidence of this rapidly progressive, irreversible neurodegenerative cerebral disorder is expected to increase further in coming years, given its close connection with advanced age, yet there are no satisfactory therapies.
其他文献
Due to the high degree of conservation of genes and mechanisms, the fruit fly Drosophila melanogaster is a powerful experimental in vivo tool to investigate complex diseases, thus complementing traditional vertebrate systems. Drosophila is also an advanta
期刊
Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue sections.Novel optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have
Autophagy has been shown to play an important role in Parkinson\'s disease.We hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson\'s disease through affecting autophagy.In this study,6-hydroxydopamine-damaged SH
The mechanism of AD remains uncovered:The current mainstream doctrine in Alzheimer\'s disease (AD) is the amyloid cascade hypothesis. According to this hypothesis, amyloid-β (Aβ) deposition is the main reason for neurofibrillary tangles formation and sy
期刊
Severe cerebral ischemia/reperfusion injury has been shown to induce high-level autophagy and neuronal death. Therefore, it is extremely important to search for a target that inhibits autophagy activation. Long non-coding RNA MEG3 participates in autophag
The nervous system is a highly complex organization composed of its basic unit, the neuronal cells, and specialized supporting cells, the glial cells. The main glial cells in the central nervous system (CNS) are astrocytes, microglia and oligodendrocytes.
期刊
Mutations that cause protein misfolding are implicated in conditions such as retinitis pigmentosa (RP), Usher Syndrome, and myocilin associated primary open angle glaucoma. The aggregation and continuous degradation of a highly abundant misfolded protein
期刊
The mouse model of oxygen induced retinopathy is suitable for the study of various retinal neovascularization diseases,including retinopathy of prematurity.The maternally expressed gene 3(MEG3)has been demonstrated to have an inhibitory effect on diabetic
Wallerian degeneration is a complex biological process that occurs after nerve injury, and involves nerve degeneration and regeneration.Schwann cells play a crucial role in the cellular and molecular events of Wallerian degeneration of the peripheral nerv
Electron microscopy (EM) provides a unique ability to visualize structural detail with a resolution orders of magnitude better than other imaging techniques. Applied conventionally, its limitation is that each acquired image represents a small area with a
期刊