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目的探讨宫颈常规细胞学和DNA定量分析方法联合诊断在宫颈CIN Ⅲ及以上级别宫颈病变中的应用价值。方法对我院宫颈防癌普查的8448名妇女分别行常规细胞学及细胞DNA倍体分析,并做出联合诊断建议。结果以活检结果为诊断金标准,在1041例活检病例中,计算出常规细胞学ASC-H以上者105例,在CIN Ⅲ及以上级别宫颈病变中敏感性为39%,特异性为94.4%,细胞DNA倍体分析中异常倍体细胞≥3个共253例,在CIN Ⅲ及以上级别宫颈病变中敏感性为74.5%,特异性为83.6%,而常规细胞学与DNA定量分析联合诊断阳性结果为308例,敏感性为80.9%,特异性为78.4%。结论常规细胞学与DNA定量分析方法的联合检测可提高CIN Ⅲ及以上级别宫颈病变中的检出率,减少漏诊,有利于宫颈病变的早期诊断及早期治疗。
Objective To investigate the value of cervical cytology and DNA quantitative analysis in cervical intraepithelial neoplasia (CIN Ⅲ) and above. Methods 8448 women in our hospital cervical cancer prevention routine routine cytology and DNA ploidy analysis and make recommendations for joint diagnosis. Results The biopsy results were the gold standard of diagnosis. Among the 1041 biopsy cases, 105 cases were diagnosed as ASC-H or more, the sensitivity and specificity were 39% and 94.4% respectively in CIN Ⅲ and above cervical lesions, There were 253 cases with abnormal ploidy≥3 in cell DNA ploidy analysis, 74.5% and 83.6% in CIN Ⅲ and above cervical lesions, while routine cytology and DNA quantitative analysis combined with positive results In 308 cases, the sensitivity was 80.9% and the specificity was 78.4%. Conclusion The combined detection of conventional cytology and DNA quantitative analysis can improve the detection rate of cervical lesions of CIN Ⅲ and above, reduce the missed diagnosis, and be helpful for the early diagnosis and early treatment of cervical lesions.