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作者等对38例男性晚期、但病情稳定的慢性肺部疾患患者(平均年龄为62岁),用24小时动态心电图(Holtermonitoring)检查方法,了解静脉注射治疗剂量氨茶硷对心律的影响,并观察血清茶硷浓度与心室功能改变的关系。血清茶硷浓度为7.4~18.6mg/L。注射氨茶硷后,肺功能及血气检查比注射前有明显进步。38例中,只有3例(8%)出现新的室上性心动过速。在注射氨茶硷前仅有少数室性期外收缩的21例患者中(24小时动态心电图检查<5次室性期外收缩/小时),16例(76%)注射氨茶硷时没有改变;
The authors studied the effects of intravenous treatment with aminophylline on cardiac rhythm in 38 patients with late-stage, but stable, chronic lung disease (mean age, 62 years) with 24-hour Holter monitoring, The relationship between serum theophylline concentration and ventricular function was observed. Serum theophylline concentration of 7.4 ~ 18.6mg / L. After injection of ammonia theophylline, lung function and blood gas examination significantly improved than before injection. Of the 38 patients, only 3 (8%) experienced new supraventricular tachycardias. Of the 21 patients who had only a few ventricular extrasystoles before aminophylline injection (<5 ventricular extrasystoles per hour on 24-hour ambulatory ECG) and 16 (76%) did not change on aminophylline infusion ;