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目的分析口服75 g葡萄糖耐量试验(OGTT)三时点血糖值与孕妇妊娠结局的相关性。方法选取2015年1—12月于复旦大学附属上海市第五人民医院产科住院分娩的妊娠期糖尿病(GDM)患者125例、正常妊娠妇女157例为研究对象,分为GDM组和对照组,分析三时点血糖值与妊娠结局的相关性。结果 OGTT 1 h血糖值所确定的GDM与产后出血、新生儿窒息的发生率之间关联,列联系数分别为r=0.015,r=0.144,差异有统计学意义(P<0.01);OGTT 2 h血糖所确定的GDM与新生儿窒息的发生率之间关联,列联系数分别为r=0.143,差异有统计学意义(P<0.01)。结论在GDM患者中,OGTT 1 h、2 h血糖值与新生儿窒息存在相关性,OGTT 1 h血糖值与产后出血存在相关性,因此,对于这两时点异常的GDM患者需警惕新生儿窒息、产后出血的发生。
Objective To analyze the correlation between the blood sugar level at three orally administered 75 g glucose tolerance test (OGTT) and pregnancy outcome in pregnant women. Methods From January to December 2015, 125 pregnant women with gestational diabetes mellitus (GDM) who were hospitalized in Shanghai Fifth People’s Hospital affiliated to Fudan University and 157 normal pregnant women were enrolled in this study. The patients were divided into GDM group and control group. Three o’clock blood glucose levels and pregnancy outcomes. Results The correlation between GDM and postpartum hemorrhage and neonatal asphyxia determined by OGTT 1 h blood glucose level was: r = 0.015, r = 0.144, the difference was statistically significant (P <0.01); OGTT 2 h blood glucose determined by the GDM and the incidence of neonatal asphyxia, the association coefficients were r = 0.143, the difference was statistically significant (P <0.01). Conclusions In GDM patients, there is a correlation between blood glucose level at 1 h and 2 h of OGTT and neonatal asphyxia. The blood glucose level at 1 h after OGTT is correlated with postpartum hemorrhage. Therefore, we need to guard against neonatal asphyxia , The occurrence of postpartum hemorrhage.