新生儿败血症是导致新生儿死亡和致残的重要疾病,早期诊断具有重要意义。近年来,细胞因子、降钙素原、中性粒细胞表面抗原、细胞间黏附分子、中性粒细胞弹性蛋白酶抑制剂及纤维连接蛋白等生物学参数被作为败血症的早期标志物来进行研究。现将其作用机制及临床应用作一综述。 Neonatal sepsis is an important disease leading to neonatal death and disability, early diagnosis is of great significance. In recent years, biological parameters such as cytokines, procalcitonin, neutrophil surface antigen, intercellular adhesion molecule, neutrophil elastase inhibitor and fibronectin have been investigated as early markers of sepsis. Now its mechanism of action and clinical application as a review.