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目的研究沉降篮对盐酸罗匹尼罗缓释片释放度的影响。方法在FDA推荐的释放度检测方法基础上,比较增加沉降篮前后,盐酸罗匹尼罗缓释片在各取样时间点释放度的变化情况。结果增加沉降篮后,盐酸罗匹尼罗缓释片释放度结果没有明显变化,但相同时间点不同片之间RSD明显变小。结论沉降篮可以有效控制盐酸罗匹尼罗缓释片位置,得到稳定的结果,更有利于产品质量控制。
Objective To study the effect of settlement baskets on the release of ropinirole hydrochloride sustained-release tablets. Methods Based on the FDA recommended release test method, the changes of release of ropinirole hydrochloride tablets at each sampling time were compared before and after the settlement basket was increased. Results After the settlement basket was added, the release of ropinirole hydrochloride sustained-release tablets did not change significantly, but the RSD of different tablets was obviously smaller at the same time point. Conclusion The settlement basket can effectively control the position of ropinirole hydrochloride sustained-release tablets and obtain stable results, which is more conducive to product quality control.