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目的:研究子痫前期围生婴儿不良结局及其高危影响因素。方法:选取2015年7月至2016年5月湛江市霞山妇幼保健院产科门诊建卡进行产前检查80例初产单胎孕妇给予常规产检,并对产妇随访直至分娩。按照发病孕周不同将初产妇分成A、B两组。其中,A组在妊娠20周时,检测外周血中胎儿血红蛋白、血脂以及血清尿酸水平异常。B组在妊娠28周时检测外周血中胎儿血红蛋白、血脂以及血清尿酸水平异常。统计比较两组胎儿外周血血红蛋白(Hb F)、总血红蛋白(Hb T)水平,产妇总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、尿酸(UA)含量以及不良妊娠结局比例。结果:B组患者外周血液中的Hb F及Hb T水平显著优于A组,差异具有统计学意义(P<0.05);B组孕妇血清中TC、TG、LDL-C、HDL-C以及UA等指标水平显著优于A组,差异具有统计学意义(P<0.05);B组不良围产结局出现比例相较于A组明显更低,差异具有统计学意义(P<0.05)。结论:子痫发病孕周不同是影响子痫前期围生婴儿不良结局的重要危险因素,孕周越早,围产婴儿存活率以及预后质量越低。
Objective: To study the adverse outcomes of perinatal infants with preeclampsia and its risk factors. Methods: From July 2015 to May 2016, 80 cases of primiparous singleton pregnant women were given prenatal examination by prenatal checkup card in Zheshan Xiaoshan Maternity and Child Health Hospital, and maternal follow-up until delivery. In accordance with the different gestational weeks will be divided into primipara A, B two groups. Among them, in group A, fetus hemoglobin, serum lipids and serum uric acid levels in peripheral blood were detected abnormally at 20 weeks gestation. B group at 28 weeks of gestation to detect fetal hemoglobin in peripheral blood, serum lipids and serum uric acid levels were abnormal. The levels of Hb F, Hb T, TC, TG, LDL-C, HDL-C, Protein-cholesterol (HDL-C), uric acid (UA) content and adverse pregnancy outcomes. Results: The levels of Hb F and Hb T in peripheral blood of group B were significantly better than those of group A (P <0.05). The level of TC, TG, LDL-C, HDL-C and UA (P <0.05). The proportion of adverse perinatal outcomes in group B was significantly lower than that in group A (P <0.05). Conclusion: The different gestational age of eclampsia is an important risk factor affecting the outcome of perinatal infants with preeclampsia. The earlier the gestational age, the lower the survival rate of perinatal infants and the quality of prognosis.