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目的了解新疆女性人乳头状瘤病毒(HPV)基因亚型及年龄分布,并对HPV感染特征进行分析。方法对2011年1月─2013年12月在新疆医科大学第二附属医院妇科就诊的3 167例女性患者,进行HPV感染基因亚型检测。结果 3 167例女性患者标本,检出HPV阳性者977例,总阳性率为30.81%;HPV感染的各亚型分布中其感染频度前八位依次为HPV52型、HPV16型、HPV58型、HPV18型、HPV33型、HPV6型、HPV66型、HPV53型;单一种感染739例,占75.6%;2种感染161例,占16.48%;3种感染70例,占7.20%;4种感染7例,占0.72%;HPV总感染率及高危亚型随年龄增长升高,低危亚型感染率随年龄增长呈下降趋势;不同年龄组HPV感染检出率差异有统计学意义(χ2=32.15,P<0.05)。结论该调查女性HPV感染基因亚型符合亚洲人群分布规律,HPV高危亚型感染年龄主要分布在40岁以上人群中,如能做到早发现、早诊断、早治疗,完全可以预防宫颈癌的发生。
Objective To understand the genotype and age distribution of human papillomavirus (HPV) in Xinjiang and to analyze the characteristics of HPV infection. Methods A total of 3 167 female patients with gynecological disease in the Second Affiliated Hospital of Xinjiang Medical University from January 2011 to December 2013 were genotyped for HPV infection. Results A total of 977 HPV positive cases were detected in 3 167 female patients, with a total positive rate of 30.81%. The top eight of HPV subtypes were HPV52, HPV16, HPV58 and HPV18 7 cases were single infection, accounting for 75.6%; 161 cases were two infections, accounting for 16.48%; 70 cases were infected by three kinds, accounting for 7.20%; 7 cases were infected by four kinds of infection, Accounting for 0.72%. The total HPV infection rate and high-risk subtypes increased with age, and the infection rate of low-risk subtype decreased with age. The detection rate of HPV infection in different age groups was statistically different (χ2 = 32.15, P <0.05). Conclusion The survey of female genotypes of HPV infection in line with the distribution of Asian populations, HPV high risk subtypes of age are mainly distributed in people over the age of 40, if they can do early detection, early diagnosis and early treatment, can prevent the occurrence of cervical cancer .