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为了探讨铅影响学习记忆功能的作用机制，作者进行了海马突触小体递质摄取实验。结果显示：３．１～５０．０μｍｏｌ／Ｌ剂量铅在体外作用１５分钟，能使突触小体３Ｈ－ＤＬ－谷氨酸摄取率增加７０．３８％～１９３．２４％，且存在明显的剂量效应关系。动物先经１０～１６００μｇ／ｍｌ剂量铅饮水染毒３０天，然后直接进行摄取实验，摄取率增加６５．７３％～１２４．９３％，与海马组织中铅含量存在剂量效应关系。提示铅离子能直接加速谷氨酸递质的灭活，产生抑制性作用。
In order to investigate the mechanism by which lead affects learning and memory, we performed experiments on neurotransmitter uptake in the hippocampus. The results showed that 3.1 ~ 50.0μmol / L lead in vitro for 15 minutes, the synaptosome 3H-DL-glutamate uptake rate increased 70.38% ~ 193.24%, and there is significant Dose-effect relationship. The animals were treated with lead drinking water of 10 ~ 1600μg / ml for 30 days and then directly ingested. The uptake rate increased by 65.73% ~ 124.93%, and there was a dose-effect relationship with lead content in hippocampus. Tip lead ions can directly accelerate the inactivation of glutamate neurotransmitter, resulting in inhibitory effect.