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目的探讨新生儿化脓性脑膜炎的临床特点和治疗转归。方法分析46例新生儿化脓性脑膜炎的临床特点、实验室检查和病原学治疗转归。结果新生儿化脓性脑膜炎最常见症状为反应差、发热和呼吸系统改变。外周血最常见的改变为贫血、白细胞升高和C反应蛋白(CRP)水平升高。B族溶血链球菌(GBS)及大肠埃希菌是最主要的病原。结论新生儿化脓性脑膜炎是新生儿严重感染性疾病之一,发病率和死亡率高。提高病原诊断率非常重要,抗菌药物需根据病原菌药敏试验以及临床经验选用合适抗生素。
Objective To investigate the clinical features and treatment outcome of neonatal purulent meningitis. Methods 46 cases of neonatal purulent meningitis clinical features, laboratory tests and pathogenic treatment outcome. Results The most common symptoms of neonatal purulent meningitis were poor response, fever and respiratory changes. The most common changes in peripheral blood are anemia, elevated white blood cells, and elevated levels of C-reactive protein (CRP). B hemolytic streptococcus (GBS) and Escherichia coli is the most important pathogen. Conclusion Neonatal purulent meningitis is one of the most serious neonatal infectious diseases with high morbidity and mortality. To improve the diagnosis of pathogen is very important, antimicrobial agents need to be based on pathogen susceptibility testing and clinical experience appropriate antibiotics.