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1978年作者用心得安治疗1例患者发作性睡病的室性早搏的病人,发现用小剂量时能使睡病和猝倒症的发作减少,当剂量加大到约300mg/日时发作消失.本文报导另4例的治疗效果.睡病发作平均18年(8~44年),猝倒症发作平均14年(5~40年)所有病例均用过利他灵治疗多年,均产生某种程度耐药性.患者住院治疗并经心脏科医生检查且同意用大剂量心得安.疾病的发作都要记下发生的时间、持续期限和发作前情况.在三天内逐渐停用利他灵,以后用单盲法评价每例安慰剂——心得安的疗效,
In 1978, the author used propranolol to treat patients with narcolepsy in premature ventricular contractions and found that the onset of narcolepsy and cataplexy with a small dose reduced, and the episode disappeared when the dosage was increased to about 300 mg / day .This article reported the treatment effect of the other 4 cases.The average onset of the disease was 18 years (8 to 44 years), and the average episode of cataplexy was 14 years (5 to 40 years). All the cases were treated with Ritalin for many years, Degree of drug resistance. Patients hospitalized and checked by cardiologists and agreed to use high-dose propranolol. Attack of the disease should note the occurrence of time, duration and pre-attack situation. Ritalin gradually disabled in three days later Each placebo was evaluated in a single blinded fashion - propranolol,