Molecular Docking and 3D-QSAR Studies on a Series of Fused Heterocyclic Amides as B-Raf Inhibitors

来源 :结构化学 | 被引量 : 0次 | 上传用户：s83436776

【摘要】

：

B-Raf has been identified as promising targets for novel anticancer agents. To further explore the interactions between small molecules and B-Raf, and to elucid

【作者】

：

WANG Lu ZHANG Yan-Min LU Shuai

【机构】

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SchoolofBasicScience,StateKeyLaboratoryofNaturalMedicines

【出处】

：

结构化学

【发表日期】

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2017年9期

【关键词】

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3D-QSAR 分子对接抑制剂比较分子相似性指数分析三维定量构效关系 QSAR模型 COMSIA CoMFA B-Raf molecular docki

【基金项目】

：

supported by the National Natural Science Foundation of China（21572273）

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B-Raf has been identified as promising targets for novel anticancer agents. To further explore the interactions between small molecules and B-Raf, and to elucidate structural characteristics that influence the B-Raf kinase activity, molecular docking and

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Molecular Docking and 3D-QSAR Studies on a Series of Fused Heterocyclic Amides as B-Raf Inhibitors

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