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目的探讨E-钙粘素在子宫内膜异位症的异常表达及意义。方法应用免疫组织化学及图像分析方法比较E-钙粘素在正常子宫内膜、内膜异位症在位及异位内膜中的量。结果正常子宫内膜和内膜异位症在位内膜腺上皮E-钙粘素的表达无明显的周期性变化。在整个月经周期中,内膜异位症在位内膜腺上皮E-钙粘素的表达显著低于同期正常子宫内膜。卵巢子宫内膜异位囊肿中异位内膜腺上皮E-钙粘素的表达显著低于同组患者的在位内膜。结论子宫内膜异位症在位和异位内膜腺上皮E-钙粘素的表达降低与内膜异位症的发病密切相关。
Objective To investigate the abnormal expression of E-cadherin in endometriosis and its significance. Methods The quantity of E-cadherin in eutopic and ectopic endometrium of normal endometrium and endometriosis was compared by immunohistochemistry and image analysis. Results There was no obvious periodic change in the expression of E-cadherin in normal endometrium and endometriosis. Eutopic endometrial glandular epithelial E-cadherin expression was significantly lower in endometriosis than in normal endometrium during the entire menstrual cycle. Ectopic endometrial epithelial E-cadherin expression in ovarian endometriotic cysts was significantly lower than that in the same group of patients. Conclusion The decreased expression of E-cadherin in eutopic and ectopic endometriosis of endometriosis is closely related to the pathogenesis of endometriosis.