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目的探讨经肠内营养补充谷氨酰胺对血清蛋白的影响。方法将2013年5月至2014年12月在该院住院的低蛋白血症患者60例随机分为观察组和对照组,每组30例。对照组给予普通肠内营养支持15 d,观察组在对照组基础上给予补充谷氨酰胺的肠内营养支持15 d。观察两组患者营养支持前后血清免疫球蛋白(Ig A、Ig G、Ig M)、清蛋白(ALB)、前清蛋白(PA)及总蛋白(TP)的变化。结果观察组营养支持后的Ig A、ALB、PA水平均高于治疗前,对照组患者营养支持后的PA明显高于治疗前,差异均有统计学意义(P<0.05);营养支持后,观察组的Ig A、ALB、PA水平均优于对照组,差异均有统计学意义(P<0.05)。结论经肠内营养补充谷氨酰胺能明显提高低蛋白血症患者血清Ig A、ALB和PA水平。
Objective To investigate the effect of enteral nutrition supplementation of serum glutamine on serum protein. Methods 60 patients with hypoalbuminemia who were hospitalized in this hospital from May 2013 to December 2014 were randomly divided into observation group and control group with 30 cases in each group. The control group was given general enteral nutrition for 15 days. The observation group was given enteral nutrition for glutamine supplementation for 15 days on the basis of the control group. The changes of serum immunoglobulin (Ig A, Ig G, Ig M), albumin (ALB), prealbumin (PA) and total protein (TP) before and after nutrition support were observed in both groups. Results The levels of IgA, ALB and PA after nutritional support in the observation group were significantly higher than those before treatment. The PA after nutritional support in the control group was significantly higher than that before treatment (P <0.05). After nutritional support, The levels of Ig A, ALB and PA in the observation group were better than those in the control group, with significant differences (P <0.05). Conclusions Glutamine supplementation with enteral nutrition can significantly increase serum Ig A, ALB and PA levels in patients with hypoproteinemia.