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来曲唑是第3代芳香酶抑制药,主要通过抑制雌激素合成,减少其对下丘脑-垂体的负反馈抑制,促进促性腺激素合成,进而发挥诱导排卵作用。临床初步研究表明,来曲唑能较安全有效地应用于排卵障碍(尤其是对氯米芬治疗效果不佳者)以及辅助生殖技术的诱导排卵过程,及年轻乳腺癌患者生育力保存而行控制性超排卵的过程。本文就来曲唑排卵诱导作用的研究进展作一综述。
Letrozole is the third generation of aromatase inhibitors, mainly by inhibiting estrogen synthesis, reducing its negative feedback inhibition of the hypothalamus - pituitary gonadotropin to promote synthesis, and then play an inductive role in ovulation. Preliminary clinical studies have shown that letrozole can be more safely and effectively applied to ovulation disorders (especially those who do not respond well to clomiphene), assisted ovulation induction, and control of fertility in young breast cancer patients Sexual ovulation process. This review summarizes the research progress of the induction of letrozole by ovulation.