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实验证明,血浆CAMP水平可反映β肾上腺素能神经功能状况,cGMP水平可反映胆碱能神经功能状况,对两者进行测定,可在一定程度上反映整体条件下植物神经的功能状态。本协作组曾用以大剂量山莨菪碱(654-2)为主的综合治疗,使感染性休克患者病死率明显降低。为阐明休克过程中神经体液因子如何调节把细胞的功能,从细胞水平探讨休克过程的某些病理生理机制以及654-2抗休克作用原理,设计了本课题的研究。材料和方法实验用成年健康杂种狗,14～26kg,共52条,分五组。第I组6条:生理盐水1.5ml/kg一次静注;第
Experiments show that plasma CAMP levels can reflect β-adrenergic neurological status, cGMP levels reflect the status of cholinergic nerve function, both to determine, to a certain extent, reflect the functional status of the autonomic nervous system. This group has used large doses of anisodamine (654-2) -based comprehensive treatment, so that patients with septic shock mortality was significantly lower. To clarify how neurohumobiological factors regulate the function of cells during shock, we investigated some pathophysiological mechanisms of shock process at the cellular level and the anti-shock mechanism of 654-2, and designed the research of this topic. Materials and Methods Experimental adult healthy mongrel dogs, 14 ~ 26kg, a total of 52, divided into five groups. Group I 6: saline 1.5ml / kg once intravenous;