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目的 :探讨支气管哮喘与结合珠蛋白的遗传多态性的关系。方法 :聚丙烯酰胺凝电泳技术研究患者和正常人HP型分布特点 ,并计算HP1基因频率 ,比较两组间的统计学差异。结果 :0～ 5 0岁哮喘病人HP1基因频率显著高于正常人 ;外源性哮喘组HP1基因频率高于正常对照组 ,内源性组则与正常对照组无显著差异。结论 :四川地区HP1基因与哮喘发生有关 ,可能主要在外源性哮喘中起作用。
Objective: To investigate the relationship between bronchial asthma and haptoglobin genetic polymorphism. Methods: Polyacrylamide gel electrophoresis technique was used to study the distribution of HP type in patients and normal subjects, and the frequency of HP1 gene was calculated. The statistical difference between the two groups was compared. Results: The frequency of HP1 gene in asthmatics from 0 to 50 years old was significantly higher than that in normal people. The frequency of HP1 gene in extrinsic asthma group was higher than that in normal control group. There was no significant difference between endogenous group and normal control group. Conclusion: The HP1 gene in Sichuan is related to the development of asthma and may play a major role in exogenous asthma.