硬皮病和有硬皮病特征的重叠结缔组织病综合征患者的肌肉受侵已有报告,但早期的研究未能区别这些患者的肌肉病变是硬皮病的直接结果还是第二种疾病的重叠。目前,肌肉受侵作为硬皮病的一种表现正在引起人们的注意。本文对14例硬皮病和伴发硬皮病的“重叠”综合征患者进行了肌病的临床、实验室和病理学表现的分析研究。14例患者均符合弥漫性硬皮病、CREST综合征、或具有硬皮病和中等严重性慢性炎性关节炎表现的一种“重叠”综合征的诊断标准。研究结果示所有患者都有对称性近端肌无力,3例还有肌痛。2例经神经传导研究不 Muscle involvement in patients with overlapping connective tissue disease syndrome characterized by scleroderma and scleroderma has been reported but early studies failed to distinguish whether these patients’ muscle lesions were the direct result of scleroderma or the second disease overlapping. Currently, muscular involvement as a manifestation of scleroderma is attracting attention. In this paper, 14 cases of scleroderma and scleroderma patients with “overlap” were analyzed for clinical, laboratory and pathological findings of myopathy. All 14 patients met the diagnostic criteria for diffuse scleroderma, CREST syndrome, or an “overlap syndrome” with a manifestation of scleroderma and moderate-severity chronic arthritis. The study showed that all patients had symmetrical proximal weakness and 3 had myalgia. Two cases of neurotransmission did not