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目的:通过双向性队列研究,探讨完全性切除术后Ⅲa期非小细胞肺癌(NSCLC)患者无病生存期(DFS)的相关预后因素。方法:纳入240例Ⅲa期非小细胞肺癌完全切除术后行辅助化疗的患者,使用Kaplan-Meire法计算患者的1、3、5年无病生存率和DFS,对可能的预后影响因素进行单因素分析,并对有显著差异的预后因素进行COX多因素回归模型分析。结果:240例患者的1年无病生存率为83.33%(200/240),3年无病生存率为33.33%(80/240),5年无病生存率为10.42%(25/240),中位DFS为26.22个月。单因素分析结果显示,性别、吸烟史是影响患者DFS的预后相关因素(P<0.05);多因素分析显示,性别(P=0.026)、吸烟史(P=0.034)是影响患者DFS的独立预后因素。结论:性别、吸烟史是影响Ⅲa期非小细胞肺癌完全性切除术后患者DFS的独立预后因素。
Objective: To investigate the prognostic factors of disease-free survival (DFS) in patients with stage Ⅲ a non-small cell lung cancer (NSCLC) after complete resection through bidirectional cohort study. Methods: A total of 240 patients with stage Ⅲa non-small cell lung cancer who received adjuvant chemotherapy after complete resection were enrolled. The 1, 3, 5 year disease-free survival and DFS were calculated by Kaplan-Meire method. The possible prognostic factors Factor analysis, and significant differences in prognostic factors COX multivariate regression model analysis. Results: One-year disease-free survival rates were 83.33% (200/240) in 240 patients, 33.33% (80/240) in 3 years, and 10.42% (5/240) in 5 years , Median DFS was 26.22 months. Univariate analysis showed that gender and smoking history were the prognostic factors influencing DFS in patients (P <0.05). Multivariate analysis showed that gender (P = 0.026) and smoking history (P = 0.034) were independent prognostic factors in patients with DFS factor. Conclusion: Gender and smoking history are the independent prognostic factors of DFS in patients with stage Ⅲa non-small cell lung cancer after complete resection.