目的研究锌转运体-1(zinc transporter1,ZnT-1)在小鼠肾脏的定位分布。方法应用免疫组织化学技术和免疫印迹技术检测小鼠肾脏中ZnT-1的分布。结果 ZnT-1在肾脏内有丰富表达,其主要分布于远曲小管上皮细胞的近腔侧和基底侧的细胞膜上,而在肾小体、肾小管的其它部分以及髓质中的分布较少。结论小鼠肾脏内含有丰富的ZnT-1,ZnT-1可能参与了锌离子在肾脏的排泄和重吸收过程。 Objective To study the localization of zinc transporter1 (ZnT-1) in mouse kidney. Methods Immunohistochemistry and Western blotting were used to detect the distribution of ZnT-1 in the kidney of mice. Results ZnT-1 was abundantly expressed in the kidney and mainly distributed on the cell membrane near the parietal and basal sides of distal tubule epithelial cells, but not in the renal tubules, other parts of renal tubules and medulla . Conclusion The kidney of mice is rich in ZnT-1. ZnT-1 may be involved in the excretion and reabsorption of zinc ions in the kidneys.