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We developed a fixation method and evaluate bone regrowth in the cavities of a Ф4 mm× 8 mm titanium(Ti)tube through porous hydroxyapatite(HAP)/β-tricalcium phosphate(β-TCP)composite filling(group A),chitosan/calcium phosphate composite filling(group B),and HAP particle modification(group C).After 2 and 5 months of implantation in dog tibia defects,new bone formation in the three groups was studied by histology and histomorphometry.Group A displayed the most bone regenerated area in both 2 and 5 months post-operation.The chitosan/calcium phosphate composite in group B mostly degraded 2 months after implantation,leading to fibrous tissue invasion after 5 months.By contrast,less bone formation was observed in group C.These results indicated that filling the cavities of metalprostheses with a porous HAP/β-TCP composite can be used for stable long-term fixation in clinicalsettings.
We developed a fixation method and evaluate bone regrowth in the cavities of a Ф4 mm × 8 mm titanium (Ti) tube through porous hydroxyapatite (HAP) / β-tricalcium phosphate (β-TCP) composite filling (group A) phosphate composite filling (group B), and HAP particle modification (group C). After 2 and 5 months of implantation in dog tibia defects, new bone formation in the three groups was studied by histology and histomorphometry. Group A displayed the most bone regenerated area in both 2 and 5 months post-operation. The chitosan / calcium phosphate composite in group B mostly degraded 2 months after implantation, leading to fibrous tissue invasion after 5 months. By contrast, less bone formation was observed in group C. These results indicated that filling the cavities of metal prostheses with a porous HAP / β-TCP composite can be used for stable long-term fixation in clinical settings.