抵抗素是由Steppan等在2001年首先报道的由脂肪细胞分泌的富含半胱氨酸的肽类激素,并经鼠模型证实其可能为肥胖和2型糖尿病的连接点,或至少部分说明了肥胖和2 型糖尿病之间的关系。但也有研究显示,在正常人2型糖尿病的肌肉组织和孤立的脂肪细胞中抵抗素的表达没有发现不同。人类抵抗素是否有与鼠类抵抗素有相似的作用,尚难定论。为此,我们进行了该实验以探讨人血清抵抗素水平与肥胖、胰岛素抵抗之间的关系。 Resistin is a cysteine-rich peptide hormone secreted by adipocytes first reported by Steppan et al. In 2001 and confirmed by murine models that it may be the junction of obesity and type 2 diabetes, or at least in part The relationship between obesity and type 2 diabetes. However, other studies have shown no difference in the expression of resistin in normal human type 2 diabetes mellitus and isolated adipocytes. Whether human resistin has a similar effect with that of mouse resistin is yet to be determined. To do this, we conducted this experiment to investigate the relationship between human serum resistin levels and obesity and insulin resistance.