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本文综述有关钙、磷调节1-α羟化酶活性的研究及镁缺乏情况下维生素D的代谢情况。 酶复合体 人类1-α羟化酶复合体主要存在于肾小管线粒体内。多数哺乳动物研究结果提示该酶复合体位于近曲小管。该酶由黄素蛋白、缺氧还原蛋白铁蛋白和细胞色素P-450构成。这些成分定位于线粒体内膜。PTH是
This review summarizes the studies on the regulation of 1-α-hydroxylase activity by calcium and phosphorus and the vitamin D metabolism in the absence of magnesium. Enzymes complex The human 1-alpha hydroxylase complex is mainly found in the renal tubular mitochondria. Most mammalian studies suggest that the enzyme complex is located in the proximal tubule. This enzyme consists of flavoprotein, hypoxanthin ferritin and cytochrome P-450. These components are localized to the mitochondrial inner membrane. PTH is