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一个大大出人意料的事实突然展现在我们面前,以往被视为几无疗效的一组抗生素,突然间已成为化疗武库中某个重要部分之潜在威力。奎诺酮类药物的第一个成员是萘啶酸。尽管它对多种泌尿系病原体有效,然而在以往用于治疗泌尿遭感染时,多因细菌抗药性的快速产生以及某些有内在抗药性的菌种如绿脓杆菌、葡萄球菌、肠球菌的双重感染而招致失败。本世纪七十年代,合成了吡哌酸、其抗菌能力略强于前者。但是,更加新的奎诺酮类药物如4—奎诺酮、norflox-acin、Pefloxain,enoxacin、ofloxacin、
A surprisingly large number of facts suddenly appearing before us, previously seen as a curative drug of ineffectiveness, have suddenly become the potential force of an important part of the arsenal of chemotherapy. The first member of quinolones is nalidixic acid. Although it is effective against many urological pathogens, it is often used in the treatment of urinary tract infections due to the rapid generation of bacterial resistance and certain intrinsically drug-resistant bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus Double infection led to failure. In the seventies of this century, pipemidic acid was synthesized, its antibacterial ability slightly stronger than the former. However, newer quinolones such as 4-quinolone, norflox-acin, Pefloxain, enoxacin, ofloxacin,