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目的 探讨血清转化生长因子 β1(TGF β1)对肾细胞癌侵袭性的作用。方法 应用酶联免疫吸附试验 (ELISA)方法对 17例肾细胞癌患者根治术前后血清TGF β1浓度和 17例行体外冲击波碎石患者 ,17例前列腺增生患者及 17例正常人血清TGF β1浓度进行测定。结果 所有肾细胞癌根治术前患者血清TGF β1水平明显高于正常对照组 (P <0 0 0 1) ,根治术后患者TGF β1浓度明显下降 (P <0 0 1)。结论 血清TGF β1浓度有可能成为一种判断肾细胞癌预后的瘤标。
Objective To investigate the effect of transforming growth factor-β1 (TGF-β1) on the invasiveness of renal cell carcinoma. Methods Serum levels of TGF-β1 in 17 patients with renal cell carcinoma and 17 patients with extracorporeal shock wave lithotripsy, 17 patients with benign prostatic hyperplasia (BPH) and 17 normal controls were measured by enzyme linked immunosorbent assay (ELISA) Measurement was performed. Results The serum level of TGF-β1 in patients with preoperative renal cell carcinoma was significantly higher than that in the normal control group (P <0.01). The TGF-β1 level in patients with radical nephrectomy was significantly decreased (P <0.01). Conclusion The serum concentration of TGF-β1 may become a tumor marker for predicting the prognosis of renal cell carcinoma.